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Journal article

Development of inositol-based antagonists for the D-myo-inositol 1,4,5-trisphosphate receptor.

Abstract:
The syntheses of four D-myo-inositol 1,4,5-trisphosphate (InsP(3)) derivatives, incorporating phosphate bioisosteres at the 5-position, are reported. The methyl phosphate ester and sulfate derivatives retain InsP(3) receptor (InsP(3)R) agonist activity; the compounds that possess a methylphosphonate or a carboxymethyl moiety are InsP(3)R antagonists.
Publication status:
Published

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Publisher copy:
10.1039/c0cc03003a

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Journal:
Chemical communications (Cambridge, England)
Volume:
47
Issue:
1
Pages:
242-244
Publication date:
2011-01-05
DOI:
EISSN:
1364-548X
ISSN:
1359-7345
URN:
uuid:a262f828-8170-4b45-8c39-ccbd923e9331
Source identifiers:
90296
Local pid:
pubs:90296

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