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Sialylation of urinary prothrombin fragment 1 is implicated as a contributory factor in the risk of calcium oxalate kidney stone formation.

Abstract:

Urinary glycoproteins are important inhibitors of calcium oxalate crystallization and adhesion of crystals to renal cells, both of which are key mechanisms in kidney stone formation. This has been attributed to glycosylation of the proteins. In South Africa, the black population rarely form stones (incidence < 1%) compared with the white population (incidence 12-15%). A previous study involving urinary prothrombin fragment 1 from both populations demonstrated superior inhibitory activity a...

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Publication status:
Published

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Authors


Radcliffe, CM More by this author
Tobiasen, G More by this author
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Journal:
The FEBS journal
Volume:
273
Issue:
13
Pages:
3024-3037
Publication date:
2006-07-05
DOI:
EISSN:
1742-4658
ISSN:
1742-464X
URN:
uuid:a25fe062-31a7-4a8c-9a36-985c9c2a3838
Source identifiers:
99875
Local pid:
pubs:99875

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