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The selectivity of K+ ion channels: testing the hypotheses.

Abstract:

How K(+) channels are able to conduct certain cations yet not others remains an important but unresolved question. The recent elucidation of the structure of NaK, an ion channel that conducts both Na(+) and K(+) ions, offers an opportunity to test the various hypotheses that have been put forward to explain the selectivity of K(+) ion channels. We test the snug-fit, field-strength, and over-coordination hypotheses by comparing their predictions to the results of classical molecular dynamics s...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1529/biophysj.108.132035

Authors


Fowler, PW More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
Biotechnology and Biological Sciences Research Council More from this funder
Wellcome Trust More from this funder
Publisher:
Elsevier B.V. Publisher's website
Journal:
Biophysical journal Journal website
Volume:
95
Issue:
11
Pages:
5062-5072
Publication date:
2008-12-05
DOI:
EISSN:
1542-0086
ISSN:
0006-3495
URN:
uuid:a25f0e7e-1e77-477f-be28-86851980cd83
Source identifiers:
100786
Local pid:
pubs:100786

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