Semi-specific immuno-absorption and monoclonal antibody therapy in ANCA positive vasculitis: experience in four cases.

Journal article

The treatment of renal limited systemic vasculitis usually involves a combination of cytotoxic drugs and steroids. As shown by randomised prospective controlled trial, plasmapheresis may be of additional benefit for the management of patients with renal involvement severe enough to require dialysis support. Recently, growing evidence has suggested that autoantibodies to neutrophil cytoplasm (ANCA) may play a role in the pathogenesis of the primary vasculitides by promoting neutrophil mediated...

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Authors: Elliott, J; Lockwood, C; Hale, G; Waldmann, H

• Journal: Autoimmunity
• Volume: 28
• Issue: 3
• Pages: 163-171
• Publication date: 1998-01-01
• DOI: 10.3109/08916939808996285
• EISSN: 1607-842X
• ISSN: 0891-6934
• Language: English
• Keywords: Female; Plasmapheresis; Serine Endopeptidases; Adult; Peroxidase; Antibodies, Monoclonal; Antibody Specificity; Immunosorbent Techniques; Tetanus Toxoid; Aged; Humans; Antibodies, Antineutrophil Cytoplasmic; Vasculitis; Myeloblastin; Male