The competency of foregut mesenchyme in islet mesenchyme-to-epithelial transition during embryonic development.
BACKGROUND/PURPOSE: Potential for curative stem-cell treatments of juvenile-onset diabetes has focussed research into pancreatic islet development. Islets were previously thought to originate solely from embryonic pancreatic epithelium, but we have demonstrated that islets can originate from mesenchyme, that is, islet mesenchyme-to-epithelial transition. The aim of this study was to establish the competence of foregut mesenchyme during mesenchymal islet development. METHODS: Embryonic chick ...Expand abstract
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