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Down-regulation of Mpl marks the transition to lymphoid-primed multipotent progenitors with gradual loss of granulocyte-monocyte potential.

Abstract:

Evidence for a novel route of adult hematopoietic stem-cell lineage commitment through Lin-Sca-1+Kit+Flt3hi (LSKFlt3hi) lymphoid-primed multipotent progenitors (LMPPs) with granulocyte/monocyte (GM) and lymphoid but little or no megakaryocyte/erythroid (MkE) potential was recently challenged, as LSKFlt3hi cells were reported to possess MkE potential. Herein, residual (1%-2%) MkE potential segregated almost entirely with LSKFlt3hi cells expressing the thrombopoietin receptor (Mpl), whereas LSK...

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Publication status:
Published

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Authors


Anderson, K More by this author
Kharazi, S More by this author
Buza-Vidas, N More by this author
Böiers, C More by this author
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Journal:
Blood
Volume:
111
Issue:
7
Pages:
3424-3434
Publication date:
2008-04-05
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
URN:
uuid:a22e999d-645d-4b9b-a266-437a4cbdf8be
Source identifiers:
246539
Local pid:
pubs:246539

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