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Journal article

Fibrin(ogen) and neurodegeneration in the progressive multiple sclerosis cortex

Abstract:

OBJECTIVE: Neuronal loss, a key substrate of irreversible disability in multiple sclerosis (MS), is a recognised feature of MS cortical pathology of which the cause remains unknown. Fibrin(ogen) deposition is neurotoxic in animal models of MS, but has not been evaluated in human progressive MS cortex. The aim of this study was to investigate the extent and distribution of fibrin(ogen) in progressive MS cortex and elucidate its relationship with neurodegeneration. METHODS: A post-mortem cohort...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1002/ana.24997

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Department:
Oxford, MSD, Clinical Neurosciences
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Department:
Oxford, MSD, Clinical Neurosciences
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Department:
Oxford, MSD, Clinical Neurosciences
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Department:
Oxford, MSD, Primary Care Health Sciences
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Publisher:
Wiley Publisher's website
Journal:
Annals of Neurology Journal website
Volume:
82
Issue:
2
Pages:
259–270
Publication date:
2017-08-19
Acceptance date:
2017-07-12
DOI:
ISSN:
1531-8249
Pubs id:
pubs:709085
URN:
uri:a22d9273-19c4-4d8f-9b20-cc4fac19cfd9
UUID:
uuid:a22d9273-19c4-4d8f-9b20-cc4fac19cfd9
Local pid:
pubs:709085

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