Distribution of HLA-B alleles in a Ugandan HIV-infected adult population: NORA pharmacogenetic substudy of DART.

Journal article

OBJECTIVES: To determine the frequencies of HLA-B alleles in Ugandan patients in the NORA substudy of the DART trial and to compare HLA-B allele frequencies in those with and without clinically diagnosed hypersensitivity reaction (HSR). METHODS: DNA-based HLA-B genotyping was used to determine HLA alleles in 247 participants who received abacavir, including all six participants ('cases') with clinically diagnosed abacavir HSR. RESULTS: The incidence of clinical abacavir HSR in this double-bli...

Expand abstract

Authors: Munderi, P; Snowden, W; Walker, A; Kityo, C; Mosteller, M

• Publication status: Published
• Journal: Tropical medicine and international health : TM and IH
• Volume: 16
• Issue: 2
• Pages: 200-204
• Publication date: 2011-02-01
• DOI: 10.1111/j.1365-3156.2010.02688.x
• EISSN: 1365-3156
• ISSN: 1360-2276
• Language: English
• Keywords: Gene Frequency; Humans; Genotype; Double-Blind Method; Genetic Predisposition to Disease; Adult; HLA-B Antigens; Anti-HIV Agents; HIV Infections; Drug Hypersensitivity; Uganda; Nevirapine; Dideoxynucleosides; DART Trial Team