In vivo multiphoton microscopy technique to reveal the physiology of the mouse placenta.

Journal article

PROBLEM: Pregnancy is a challenge to the maternal immune system as it must defend the body against pathogens while at the same time develop immune tolerance against the fetus growing inside the uterus. Despite ex vivo techniques being used to understand these processes, in vivo techniques are missing. METHOD OF STUDY: To directly study these phenomena, we have developed a new microscope stage and surgical procedures for use in two-photon microscopy, for in vivo observation of the mouse place...

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Authors: Zenclussen, A; Olivieri, D; Dustin, M; Tadokoro, C

• Journal: American journal of reproductive immunology (New York, N.Y. : 1989)
• Volume: 68
• Issue: 3
• Pages: 271-278
• Publication date: 2012-09-01
• DOI: 10.1111/j.1600-0897.2012.01161.x
• EISSN: 1600-0897
• ISSN: 1046-7408
• Language: English
• Keywords: Fetus; Maternal-Fetal Exchange; Mice; Genes, Reporter; Placenta; Immune Tolerance; Pregnancy; Humans; Plasmodium chabaudi; Female; Malaria; Microscopy, Fluorescence, Multiphoton; Animals; Erythrocytes; Imaging, Three-Dimensional