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CD4-positive T-helper cell responses to the PASD1 protein in patients with diffuse large B-cell lymphoma.

Abstract:

BACKGROUND: Vaccine development targeting the novel immunogenic Per ARNT Sim Domain containing 1 (PASD1) cancer testis antigen represents an attractive therapeutic approach for the significant number of patients with diffuse large B-cell lymphoma who are refractory to conventional treatment. Since CD4-positive T helper cells have crucial roles in promoting and maintaining immune responses to tumor antigens, the presence of a CD4-positive T-helper immune response to the PASD1 antigen in patie...

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Authors


Ait-Tahar, K More by this author
Liggins, AP More by this author
Collins, GP More by this author
Campbell, A More by this author
Barnardo, M More by this author
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Journal:
Haematologica
Volume:
96
Issue:
1
Pages:
78-86
Publication date:
2011-01-05
DOI:
EISSN:
1592-8721
ISSN:
0390-6078
URN:
uuid:a1fe3d74-107d-4a04-8f77-cd5fcdaac9cc
Source identifiers:
246594
Local pid:
pubs:246594

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