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EFFECTS OF CATIONIC MODIFICATION ON SUPERFICIAL BINDING AND INTRACELLULAR CA-45 UPTAKE BY DECAPSULATED OB/OB MOUSE PANCREATIC-ISLETS

Abstract:

Decapsulated ob/ob mouse islets were used to examine the effects of monovalent and divalent cations on 45Ca uptake and binding as discriminated by La3+-wash technique. At 3 mM glucose (1.28 mM Ca2+), intracellular 45Ca uptake was increased 1.9-4.5-fold by omission of 125 mM Na+, 1.5-fold by omission of 1.2 mM Mg2+ and 2.3-fold by reduction of H+ (pH 8.5). Omission of 5.9 mM K+ was without effect. K+ at 30.9 mM increased 45Ca uptake 4.7-6.8-fold, whereas addition of H+ (pH 6.3) or 12 mM Mg2+ d...

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Publication status:
Published

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Authors


RORSMAN, P More by this author
SWANSTONFLATT, S More by this author
Journal:
BIOMEDICAL RESEARCH-TOKYO
Volume:
8
Issue:
3
Pages:
153-159
Publication date:
1987-06-05
ISSN:
0388-6107
URN:
uuid:a1f817a8-17e1-457d-b973-435c6884a7ba
Source identifiers:
986
Local pid:
pubs:986
Language:
English

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