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Journal article

Recombinational switching of the Clostridium difficile S-layer and a novel glycosylation gene cluster revealed by large-scale whole-genome sequencing.

Abstract:

BACKGROUND: Clostridium difficile is a major cause of nosocomial diarrhea, with 30-day mortality reaching 30%. The cell surface comprises a paracrystalline proteinaceous S-layer encoded by the slpA gene within the cell wall protein (cwp) gene cluster. Our purpose was to understand the diversity and evolution of slpA and nearby genes also encoding immunodominant cell surface antigens. METHODS: Whole-genome sequences were determined for 57 C. difficile isolates representative of the population ...

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Publication status:
Published

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Publisher copy:
10.1093/infdis/jis734

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Journal:
The Journal of infectious diseases
Volume:
207
Issue:
4
Pages:
675-686
Publication date:
2013-02-05
DOI:
EISSN:
1537-6613
ISSN:
0022-1899
URN:
uuid:a1e98cc2-3cc5-4f03-8422-e65a62f8930e
Source identifiers:
365513
Local pid:
pubs:365513

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