- Abstract:
-
BACKGROUND: Clostridium difficile is a major cause of nosocomial diarrhea, with 30-day mortality reaching 30%. The cell surface comprises a paracrystalline proteinaceous S-layer encoded by the slpA gene within the cell wall protein (cwp) gene cluster. Our purpose was to understand the diversity and evolution of slpA and nearby genes also encoding immunodominant cell surface antigens. METHODS: Whole-genome sequences were determined for 57 C. difficile isolates representative of the population ...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1093/infdis/jis734
-
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- Journal:
- The Journal of infectious diseases
- Volume:
- 207
- Issue:
- 4
- Pages:
- 675-686
- Publication date:
- 2013-02-05
- DOI:
- EISSN:
-
1537-6613
- ISSN:
-
0022-1899
- URN:
-
uuid:a1e98cc2-3cc5-4f03-8422-e65a62f8930e
- Source identifiers:
-
365513
- Local pid:
- pubs:365513
- Copyright date:
- 2013
Journal article
Recombinational switching of the Clostridium difficile S-layer and a novel glycosylation gene cluster revealed by large-scale whole-genome sequencing.
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