Association of streptomycin resistance mutations with level of drug resistance and Mycobacterium tuberculosis genotypes.

Journal article

OBJECTIVES: To determine 1) the relationship between specific streptomycin (SM) resistance mutations and the minimum inhibitory concentration (MIC), and 2) whether these mutations are preferentially associated with the Beijing genotype in Viet Nam. METHODS: A total of 131 consecutive Mycobacterium tuberculosis isolates resistant to either isoniazid (INH) or rifampicin (RMP), collected previously, were tested for SM resistance, spoligotyped and sequenced in the rpsL, rrs and gidB genes. The ...

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Authors: Nhu, N; Lan, N; Phuong, N; Chau, N; Farrar, J

• Publication status: Published
• Journal: international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease
• Volume: 16
• Issue: 4
• Pages: 527-531
• Publication date: 2012-04-01
• DOI: 10.5588/ijtld.11.0202
• EISSN: 1815-7920
• ISSN: 1027-3719
• Language: English
• Keywords: Vietnam; Streptomycin; Humans; Drug Resistance, Bacterial; Bacterial Typing Techniques; RNA, Bacterial; Tuberculosis, Multidrug-Resistant; Mycobacterium tuberculosis; Genotype; Microbial Sensitivity Tests; Antitubercular Agents; Sequence Analysis, RNA