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Conjugation of testosterone modifies the interaction of mono-functional cationic platinum(II) complexes with DNA, causing significant alterations to the DNA helix.

Abstract:

Previously a range of androgen conjugates with non-conventional platinum(II) complexes have been synthesised with the aim of enhancing cellular delivery, and which have shown increased cytotoxic activity compared with non-steroidal compounds (M. J. Hannon et al., Dalton Trans., 2010, DOI: 10.1039/c0dt00838a). To further study this, the complexes have been assessed for their ability to bind to and alter the structure of DNA. All platinum(II) complexes studied herein bind to model nucleo-bases ...

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Publication status:
Published

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Publisher copy:
10.1039/c0dt00839g

Authors


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Institution:
University of Oxford
Department:
Oxford, MPLS, Physics
Browning, MJ More by this author
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Journal:
Dalton transactions (Cambridge, England : 2003)
Volume:
39
Issue:
47
Pages:
11365-11374
Publication date:
2010-12-05
DOI:
EISSN:
1477-9234
ISSN:
1477-9226
URN:
uuid:a1d3a4e9-2718-4232-bb6a-b2c927f6a8d0
Source identifiers:
155346
Local pid:
pubs:155346

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