Conjugation of testosterone modifies the interaction of mono-functional cationic platinum(II) complexes with DNA, causing significant alterations to the DNA helix.

Journal article

Previously a range of androgen conjugates with non-conventional platinum(II) complexes have been synthesised with the aim of enhancing cellular delivery, and which have shown increased cytotoxic activity compared with non-steroidal compounds (M. J. Hannon et al., Dalton Trans., 2010, DOI: 10.1039/c0dt00838a). To further study this, the complexes have been assessed for their ability to bind to and alter the structure of DNA. All platinum(II) complexes studied herein bind to model nucleo-bases ...

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Authors: Sanchez-Cano, C; Huxley, M; Ducani, C; Hamad, A; Browning, M

• Publication status: Published
• Journal: Dalton transactions (Cambridge, England : 2003)
• Volume: 39
• Issue: 47
• Pages: 11365-11374
• Publication date: 2010-12-01
• DOI: 10.1039/c0dt00839g
• EISSN: 1477-9234
• ISSN: 1477-9226
• Language: English
• Keywords: DNA; Spectrometry, Mass, Electrospray Ionization; Platinum; Circular Dichroism; Magnetic Resonance Spectroscopy; Testosterone; Nucleic Acid Conformation; Coordination Complexes