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Inhibition of L-type calcium channels by internal GTP [gamma S] in mouse pancreatic beta cells.

Abstract:

Pretreatment of pancreatic beta cells with pertussis toxin resulted in a 30% increase in peak whole-cell Ca2+ currents recorded in the absence of exogenous intracellular guanine nucleotides. Intracellular application of 90 microM GTP[gamma S], by liberation from a caged precursor, resulted in 40% reduction of the peak Ca2+ current irrespective of whether the current was carried by Ca2+ or Ba2+. Effects on the delayed outward K+ current were small and restricted to a transient Ca(2+)-dependent...

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Publication status:
Published

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Publisher copy:
10.1007/bf00378643

Authors


Ammälä, C More by this author
Berggren, PO More by this author
Bokvist, K More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, OCDEM
Journal:
Pflugers Archiv : European journal of physiology
Volume:
420
Issue:
1
Pages:
72-77
Publication date:
1992-01-05
DOI:
EISSN:
1432-2013
ISSN:
0031-6768
URN:
uuid:a1cc0df2-fae6-45f3-b2de-b47bb9a46599
Source identifiers:
19050
Local pid:
pubs:19050

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