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The 5q- syndrome.

Abstract:

The 5q- syndrome is a distinct hematological disorder with typical laboratory, morphological, cytogenetic, molecular, and prognostic features. It is defined as a myelodysplastic syndrome with a medullary blast count <5% and an isolated interstitial deletion of the long arm of chromosome 5, including bands q31-q33. The molecular basis of this disease has not yet been fully elucidated, but there is evidence that a commonly deleted region of 1.5 Mb harbors one or several tumor suppressor gene...

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Authors


Giagounidis, AA More by this author
Germing, U More by this author
Wainscoat, JS More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Clinical Lab Sciences, Biomedical Research Centre
Journal:
Hematology (Amsterdam, Netherlands)
Volume:
9
Issue:
4
Pages:
271-277
Publication date:
2004-08-05
DOI:
EISSN:
1607-8454
ISSN:
1024-5332
URN:
uuid:a1cbd955-fa3d-47f5-8e48-77663e63ceaf
Source identifiers:
246221
Local pid:
pubs:246221

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