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Methotrexate is an alternative to azathioprine in neuromyelitis optica spectrum disorders with aquaporin-4 antibodies.

Abstract:

BACKGROUND: Neuromyelitis optica (NMO) is a severe autoimmune inflammatory disorder associated with considerable relapse-related disability. Immunosuppression is the mainstay of treatment but many patients do not tolerate first-line immunosuppressive agents, or experience ongoing relapses. OBJECTIVE: To evaluate the effectiveness and tolerability of methotrexate in aquaporin-4 antibody seropositive NMO spectrum disorders. METHODS: Retrospective observational case series of 14 aquaporin-4 ant...

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Publication status:
Published

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Publisher copy:
10.1136/jnnp-2012-304774

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Role:
Author
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Journal:
Journal of neurology, neurosurgery, and psychiatry
Volume:
84
Issue:
8
Pages:
918-921
Publication date:
2013-08-05
DOI:
EISSN:
1468-330X
ISSN:
0022-3050
URN:
uuid:a1c91c18-2948-4fcb-a6f2-8e17a3e7bcd4
Source identifiers:
387863
Local pid:
pubs:387863

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