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N-O-isopropyl sulfonamido-based hydroxamates: design, synthesis and biological evaluation of selective matrix metalloproteinase-13 inhibitors as potential therapeutic agents for osteoarthritis.

Abstract:

Matrix metalloproteinase-13 (MMP-13) is a key enzyme implicated in the degradation of the extracellular matrix in osteoarthritis (OA). For this reason, MMP-13 synthetic inhibitors are being sought as potential therapeutic agents to prevent cartilage degradation and to halt the progression of OA. Herein, we report the synthesis and in vitro evaluation of a new series of selective MMP-13 inhibitors possessing an arylsulfonamidic scaffold. Among these potential inhibitors, a very promising compo...

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Publication status:
Published

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Publisher copy:
10.1021/jm900261f

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Journal:
Journal of medicinal chemistry
Volume:
52
Issue:
15
Pages:
4757-4773
Publication date:
2009-08-05
DOI:
EISSN:
1520-4804
ISSN:
0022-2623
URN:
uuid:a1c0bbc8-b869-4cb3-8b86-8b3ac79d92a5
Source identifiers:
227353
Local pid:
pubs:227353

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