- Abstract:
-
Matrix metalloproteinase-13 (MMP-13) is a key enzyme implicated in the degradation of the extracellular matrix in osteoarthritis (OA). For this reason, MMP-13 synthetic inhibitors are being sought as potential therapeutic agents to prevent cartilage degradation and to halt the progression of OA. Herein, we report the synthesis and in vitro evaluation of a new series of selective MMP-13 inhibitors possessing an arylsulfonamidic scaffold. Among these potential inhibitors, a very promising compo...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1021/jm900261f
-
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- Journal:
- Journal of medicinal chemistry
- Volume:
- 52
- Issue:
- 15
- Pages:
- 4757-4773
- Publication date:
- 2009-08-05
- DOI:
- EISSN:
-
1520-4804
- ISSN:
-
0022-2623
- URN:
-
uuid:a1c0bbc8-b869-4cb3-8b86-8b3ac79d92a5
- Source identifiers:
-
227353
- Local pid:
- pubs:227353
- Copyright date:
- 2009
Journal article
N-O-isopropyl sulfonamido-based hydroxamates: design, synthesis and biological evaluation of selective matrix metalloproteinase-13 inhibitors as potential therapeutic agents for osteoarthritis.
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