DNA interstrand cross-link repair in Saccharomyces cerevisiae.

Journal article

DNA interstrand cross-links (ICL) present a formidable challenge to the cellular DNA repair apparatus. For Escherichia coli, a pathway which combines nucleotide excision repair (NER) and homologous recombination repair (HRR) to eliminate ICL has been characterized in detail, both genetically and biochemically. Mechanisms of ICL repair in eukaryotes have proved more difficult to define, primarily as a result of the fact that several pathways appear compete for ICL repair intermediates, and als...

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Authors: Lehoczký, P; McHugh, P; Chovanec, M

• Journal: FEMS microbiology reviews
• Volume: 31
• Issue: 2
• Pages: 109-133
• Publication date: 2007-03-01
• DOI: 10.1111/j.1574-6976.2006.00046.x
• EISSN: 1574-6976
• ISSN: 0168-6445
• Language: English
• Keywords: Saccharomyces cerevisiae; Humans; DNA Breaks, Double-Stranded; Nuclear Proteins; Escherichia coli; DNA Repair; DNA, Fungal; DNA Replication; DNA; Cross-Linking Reagents; Animals; DNA-Binding Proteins; DNA Damage; Recombination, Genetic; Transcription, Genetic