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Journal article

Polymer-coated polyethylenimine/DNA complexes designed for triggered activation by intracellular reduction.

Abstract:

BACKGROUND: Site-specific gene delivery requires vectors that combine stability in the delivery phase with substantial biological activity within target cells. The use of biological trigger mechanisms provides one promising means to achieve this, and here we report a transfection trigger mechanism based on intracellular reduction. METHODS: Plasmid DNA was condensed with thiolated polyethylenimine (PEI-SH) and the resulting nanoparticles surface-coated using thiol-reactive poly[N-(2-hydroxypr...

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Publication status:
Published

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Publisher copy:
10.1002/jgm.525

Authors


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Institution:
University of Oxford
Department:
Oxford, MPLS, Engineering Science
Briggs, SS More by this author
Preece, JA More by this author
Ulbrich, K More by this author
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Journal:
The journal of gene medicine
Volume:
6
Issue:
3
Pages:
337-344
Publication date:
2004-03-05
DOI:
EISSN:
1521-2254
ISSN:
1099-498X
URN:
uuid:a1a9a8c7-9beb-40ca-a3e8-d1641831d439
Source identifiers:
178916
Local pid:
pubs:178916

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