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Dynamics and orientation of N+(CD3)3-bromoacetylcholine bound to its binding site on the nicotinic acetylcholine receptor.

Abstract:

Dynamic and structural information has been obtained for an analogue of acetylcholine while bound to the agonist binding site on the nicotinic acetylcholine receptor (nAcChoR), using wide-line deuterium solid-state NMR. Analysis of the deuterium lineshape obtained at various temperatures from unoriented nAcChoR membranes labeled with deuterated bromoacetylcholine (BAC) showed that the quaternary ammonium group of the ligand is well constrained within the agonist binding site when compared wit...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.031361698

Authors


Williamson, PT More by this author
Addona, GH More by this author
Miller, KW More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
98
Issue:
5
Pages:
2346-2351
Publication date:
2001-02-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:a19c4dcb-2e3d-47c9-b921-a3639dee8074
Source identifiers:
99817
Local pid:
pubs:99817

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