Definition of transcriptional pause elements in fission yeast.

Journal article

Downstream elements (DSEs) with transcriptional pausing activity play an important role in transcription termination of RNA polymerase II. We have defined two such DSEs in Schizosaccharomyces pombe, one for the ura4 gene and a new one in the 3'-end region of the nmt2 gene. Although these DSEs do not have sequence homology, both are orientation specific and are composed of multiple and redundant sequence elements that work together to achieve full pausing activity. Previous studies on the nmt1...

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Authors: Aranda, A; Proudfoot, N

• Publication status: Published
• Journal: Molecular and cellular biology
• Volume: 19
• Issue: 2
• Pages: 1251-1261
• Publication date: 1999-02-01
• EISSN: 1098-5549
• ISSN: 0270-7306
• Language: English
• Keywords: Base Sequence; DNA, Fungal; Fungal Proteins; RNA, Messenger; Transcription, Genetic; Schizosaccharomyces; Genes, Reporter; Mutation; Genes, Fungal; RNA, Fungal; Schizosaccharomyces pombe Proteins; RNA Polymerase II