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IgG antibody responses to Plasmodium falciparum merozoite antigens in Kenyan children have a short half-life.

Abstract:

BACKGROUND: Data suggest that antibody responses to malaria parasites merozoite antigens are generally short-lived and this has implications for serological studies and malaria vaccine designs. However, precise data on the kinetics of these responses is lacking. METHODS: IgG1 and IgG3 responses to five recombinant Plasmodium falciparum merozoite antigens (MSP-119, MSP-2 type A and B, AMA-1 ectodomain and EBA-175 region II) among Kenyan children were monitored using ELISA for 12 weeks after an...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1186/1475-2875-6-82

Authors


Kinyanjui, SM More by this author
Conway, DJ More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Tropical Medicine
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Funding agency for:
Marsh, K
Publisher:
BioMed Central Ltd. Publisher's website
Journal:
Malaria Journal Journal website
Volume:
6
Issue:
1
Pages:
Article: 82
Publication date:
2007
DOI:
EISSN:
1475-2875
ISSN:
1475-2875
URN:
uuid:a1931338-8ca3-45a6-bbcb-ea3e27c77b44
Source identifiers:
140062
Local pid:
pubs:140062

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