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Journal article

Identification of conserved subdominant HIV Type 1 CD8(+) T Cell epitopes restricted within common HLA Supertypes for therapeutic HIV Type 1 vaccines.

Abstract:

The high HIV-1 prevalence, up to 4.6% in Guinea-Bissau, West Africa, makes it a relevant location for testing of therapeutic vaccines. With the aim of performing a clinical study in Guinea-Bissau, after first testing the vaccine for safety in Denmark, Europe, we here describe the design of a universal epitope peptide-based T cell vaccine with relevance for any geographic locations. The two major obstacles when designing such a vaccine are the high diversities of the HIV-1 genome and of the hu...

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Publication status:
Published

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Publisher copy:
10.1089/aid.2012.0081

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Journal:
AIDS research and human retroviruses
Volume:
28
Issue:
11
Pages:
1434-1443
Publication date:
2012-11-05
DOI:
EISSN:
1931-8405
ISSN:
0889-2229
URN:
uuid:a179d066-163d-48f1-ab9b-17d70d9b7910
Source identifiers:
345691
Local pid:
pubs:345691

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