Identification of conserved subdominant HIV Type 1 CD8(+) T Cell epitopes restricted within common HLA Supertypes for therapeutic HIV Type 1 vaccines.

Journal article

The high HIV-1 prevalence, up to 4.6% in Guinea-Bissau, West Africa, makes it a relevant location for testing of therapeutic vaccines. With the aim of performing a clinical study in Guinea-Bissau, after first testing the vaccine for safety in Denmark, Europe, we here describe the design of a universal epitope peptide-based T cell vaccine with relevance for any geographic locations. The two major obstacles when designing such a vaccine are the high diversities of the HIV-1 genome and of the hu...

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Authors: Karlsson, I; Kløverpris, H; Jensen, K; Stryhn, A; Buus, S

• Publication status: Published
• Journal: AIDS research and human retroviruses
• Volume: 28
• Issue: 11
• Pages: 1434-1443
• Publication date: 2012-11-01
• DOI: 10.1089/aid.2012.0081
• EISSN: 1931-8405
• ISSN: 0889-2229
• Language: English
• Keywords: AIDS Vaccines; Sequence Alignment; Epitopes, T-Lymphocyte; HIV Infections; Histocompatibility Testing; Female; Molecular Sequence Data; Vaccines, DNA; Adult; Middle Aged; HLA Antigens; Male; Denmark; Predictive Value of Tests; CD8-Positive T-Lymphocytes; Humans; Guinea-Bissau; Drug Evaluation, Preclinical; HIV-1; Adolescent