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Journal article

TLR2-independent induction and regulation of chronic intestinal inflammation.

Abstract:

Interactions between the intestinal microflora and host innate immune receptors play a critical role in intestinal homeostasis. Several studies have shown that TLR2 can modulate inflammatory responses in the gut. TLR2 signals enhance tight junction formation and fortify the epithelial barrier, and may play a crucial role in driving acute inflammatory responses towards intestinal bacterial pathogens. In addition, TLR2 agonists can have direct effects on both Th1 cells and Treg. To define the r...

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Publication status:
Published

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Publisher copy:
10.1002/eji.200939669

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
Journal:
European journal of immunology
Volume:
40
Issue:
2
Pages:
516-524
Publication date:
2010-02-05
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
URN:
uuid:a179bb25-1fd1-4d1c-aa0d-f6e9edaa3dd2
Source identifiers:
6680
Local pid:
pubs:6680

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