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Independent recombination events between the duplicated human alpha globin genes; implications for their concerted evolution.

Abstract:

We have examined the molecular structure of the human alpha globin gene complex from individuals with a common form of alpha thalassaemia in which one of the duplicated pair of alpha genes (alpha alpha) has been deleted (-alpha 3-7). Restriction mapping and DNA sequence analysis of the mutants indicate that different -alpha 3.7 chromosomes are the result of at least three independent events. In each case the genetic crossover has occurred within a region of complete homology between the alpha...

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Publication status:
Published

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Publisher copy:
10.1093/nar/12.18.6965

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Molecular Medicine, Biomedical Research Centre
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Jenner Institute, Biomedical Research Centre
Bowden, DK More by this author
Weatherall, DJ More by this author
Journal:
Nucleic acids research
Volume:
12
Issue:
18
Pages:
6965-6977
Publication date:
1984-09-05
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
URN:
uuid:a1725f8c-adb0-4f46-aaac-c72e9b0d6ce1
Source identifiers:
95426
Local pid:
pubs:95426

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