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Cytoplasmic polyadenylation and cytoplasmic polyadenylation element-dependent mRNA regulation are involved in Xenopus retinal axon development.

Abstract:

BACKGROUND: Translation in axons is required for growth cone chemotropic responses to many guidance cues. Although locally synthesized proteins are beginning to be identified, how specific mRNAs are selected for translation remains unclear. Control of poly(A) tail length by cytoplasmic polyadenylation element (CPE) binding protein 1 (CPEB1) is a conserved mechanism for mRNA-specific translational regulation that could be involved in regulating translation in axons. RESULTS: We show that cyto...

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Publisher copy:
10.1186/1749-8104-4-8

Authors


Strochlic, L More by this author
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Journal:
Neural development
Volume:
4
Issue:
1
Pages:
8
Publication date:
2009
DOI:
EISSN:
1749-8104
ISSN:
1749-8104
URN:
uuid:a16875c2-1e10-447e-9794-d03201cda170
Source identifiers:
239105
Local pid:
pubs:239105

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