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Altered peptide ligands narrow the repertoire of cellular immune responses by interfering with T-cell priming.

Abstract:

Variation in epitopes of infectious pathogens inhibits various effector functions of T lymphocytes through antagonism of the T-cell receptor. However, a more powerful strategy for immune evasion would be to prevent the induction of T-cell responses. We report here mutual 'interference' with the priming of human T-cell responses by a pair of naturally occurring variants of a malaria cytotoxic T-cell epitope. Interference with priming also occurs in vivo for a murine malaria T-cell epitope. Res...

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Publication status:
Published

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Publisher copy:
10.1038/8444

Authors


Plebanski, M More by this author
Hannan, CM More by this author
Flanagan, KL More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Jenner Institute
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Journal:
Nature medicine
Volume:
5
Issue:
5
Pages:
565-571
Publication date:
1999-05-05
DOI:
EISSN:
1546-170X
ISSN:
1078-8956
URN:
uuid:a167d1ac-3917-421e-8f4c-5a39472004f8
Source identifiers:
31475
Local pid:
pubs:31475

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