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Attenuation of influenza A virus mRNA levels by promoter mutations.

Abstract:

We have engineered influenza A/WSN/33 viruses which have viral RNA (vRNA) segments with altered base pairs in the conserved double-stranded region of their vRNA promoters. The mutations were introduced into the segment coding for the neuraminidase (NA) by using a reverse genetics system. Two of the rescued viruses which share a C-G-->A-U double mutation at positions 11 and 12' at the 3' and 5' ends of the NA-specific vRNA, respectively, showed approximately a 10-fold reduction of NA levels...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Brownlee, GG More by this author
García-Sastre, A More by this author
Journal:
Journal of virology
Volume:
72
Issue:
8
Pages:
6283-6290
Publication date:
1998-08-05
EISSN:
1098-5514
ISSN:
0022-538X
URN:
uuid:a15d49fe-9b04-4332-a23a-0acdd3504b6d
Source identifiers:
27083
Local pid:
pubs:27083

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