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Thesis

Cancer metabolic pathways regulated by hypoxia

Abstract:

Metabolic reprogramming in cancer cells provides energy and important metabolites required to sustain tumour proliferation. Hypoxia represents a hostile environment that can encourage these transformations and other adaptive responses that contribute to poor prognosis and resistance to radiation and chemotherapy. Hypoxic signatures associated with worse prognosis were previously derived in different cancer types, and led to the selection of two candidates with potential metabolic implicati...

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Institution:
University of Oxford
Oxford college:
St Hugh's College
Department:
Medical Sciences Division
Role:
Author

Contributors

Role:
Supervisor
Publication date:
2013
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:a148c7a8-cb0c-4760-8073-678299fd837d
Local pid:
ora:7263
Language:
English
Keywords:
Subjects:

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