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Mutations in STAT3 and IL12RB1 impair the development of human IL-17-producing T cells.

Abstract:

The cytokines controlling the development of human interleukin (IL) 17--producing T helper cells in vitro have been difficult to identify. We addressed the question of the development of human IL-17--producing T helper cells in vivo by quantifying the production and secretion of IL-17 by fresh T cells ex vivo, and by T cell blasts expanded in vitro from patients with particular genetic traits affecting transforming growth factor (TGF) beta, IL-1, IL-6, or IL-23 responses. Activating mutations...

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Publication status:
Published

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Publisher copy:
10.1084/jem.20080321

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Journal:
Journal of experimental medicine More from this journal
Volume:
205
Issue:
7
Pages:
1543-1550
Publication date:
2008-07-01
DOI:
EISSN:
1540-9538
ISSN:
0022-1007

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