Membrane-type 5 matrix metalloproteinase is expressed in differentiated neurons and regulates axonal growth.
Expression of membrane-type (MT) 5 matrix metalloproteinase (MMP) in the mouse brain was examined. MT5-MMP was expressed in the cerebrum in embryos, but it declined after birth. In contrast, expression in the cerebellum started to increase postnatally and continued thereafter. The cells expressing MT5-MMP were postmitotic neurons that showed gelatinolytic activities. Specific expression of MT5-MMP was observed in the neurons but not in the glial cells when embryonal mouse carcinoma P19 cells ...Expand abstract
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- Cell growth and differentiation : the molecular biology journal of the American Association for Cancer Research
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