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Membrane-type 5 matrix metalloproteinase is expressed in differentiated neurons and regulates axonal growth.

Abstract:

Expression of membrane-type (MT) 5 matrix metalloproteinase (MMP) in the mouse brain was examined. MT5-MMP was expressed in the cerebrum in embryos, but it declined after birth. In contrast, expression in the cerebellum started to increase postnatally and continued thereafter. The cells expressing MT5-MMP were postmitotic neurons that showed gelatinolytic activities. Specific expression of MT5-MMP was observed in the neurons but not in the glial cells when embryonal mouse carcinoma P19 cells ...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
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Journal:
Cell growth and differentiation : the molecular biology journal of the American Association for Cancer Research
Volume:
12
Issue:
11
Pages:
573-580
Publication date:
2001-11-01
ISSN:
1044-9523
Source identifiers:
223976

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