The sex-specific associations of the aromatase gene with Alzheimer's disease and its interaction with IL10 in the Epistasis Project.

Journal article

Epistasis between interleukin-10 (IL10) and aromatase gene polymorphisms has previously been reported to modify the risk of Alzheimer's disease (AD). However, although the main effects of aromatase variants suggest a sex-specific effect in AD, there has been insufficient power to detect sex-specific epistasis between these genes to date. Here we used the cohort of 1757 AD patients and 6294 controls in the Epistasis Project. We replicated the previously reported main effects of aromatase polym...

Expand abstract

Authors: Medway, C; Combarros, O; Cortina-Borja, M; Butler, H; Ibrahim-Verbaas, C

• Publication status: Published
• Journal: European journal of human genetics : EJHG
• Volume: 22
• Issue: 2
• Pages: 216-220
• Publication date: 2014-02-01
• DOI: 10.1038/ejhg.2013.116
• EISSN: 1476-5438
• ISSN: 1018-4813
• Language: English
• Keywords: Risk; Genetic Association Studies; Gene Frequency; Male; Odds Ratio; Interleukin-10; Aromatase; Humans; Female; Sex Characteristics; Polymorphism, Single Nucleotide; Genetic Predisposition to Disease; Alzheimer Disease; Linkage Disequilibrium; Aged, 80 and over; Aged; Epistasis, Genetic; Case-Control Studies