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A PALB2-interacting domain in RNF168 couples homologous recombination to DNA break-induced chromatin ubiquitylation

Abstract:

DNA double-strand breaks (DSB) elicit a ubiquitylation cascade that controls DNA repair pathway choice. This cascade involves the ubiquitylation of histone H2A by the RNF168 ligase and the subsequent recruitment of RIF1, which suppresses homologous recombination (HR) in G1 cells. The RIF1-dependent suppression is relieved in S/G2 cells, allowing PALB2-driven HR to occur. With the inhibitory impact of RIF1 relieved, it remains unclear how RNF168-induced ubiquitylation influences HR. Here, we u...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.7554/eLife.20922

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Role:
Author
ORCID:
0000-0002-8737-1319
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Name:
European Research Council
Grant:
617485
Publisher:
eLife Sciences Publications
Journal:
eLife More from this journal
Volume:
6
Issue:
eLife 2017
Article number:
e20922
Publication date:
2017-02-27
Acceptance date:
2017-02-06
DOI:
EISSN:
2050-084X
ISSN:
2050-084X
Pmid:
28240985
Language:
English
Keywords:
Pubs id:
pubs:896166
UUID:
uuid:a135654d-9f4a-4edd-8440-1e18313125bc
Local pid:
pubs:896166
Source identifiers:
896166
Deposit date:
2019-05-20

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