Journal article
Typhoidal Salmonella human challenge studies: ethical and practical challenges and considerations for low-resource settings
- Abstract:
-
Typhoidal Salmonella is a major global problem affecting more than 12 million people annually. Controlled human infection models (CHIMs) in high-resource settings have had an important role in accelerating the development of conjugate vaccines against Salmonella Typhi.
The typhoidal Salmonella model has an established safety profile in over 2000 volunteers in high-income settings, and trial protocols, with modification, could be readily transferred to new study sites. To date, a typh... Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Authors
Funding
+ Wellcome Trust
More from this funder
Grant:
106698/Z/14/A milestone
106698/B/14/Z milestone
110305/Z/15/Z
096527/Z/11/Z
Bibliographic Details
- Publisher:
- BioMed Central Publisher's website
- Journal:
- Trials Journal website
- Volume:
- 20
- Issue:
- Supplement 2
- Pages:
- Artice: 704
- Publication date:
- 2019-12-19
- DOI:
- EISSN:
-
1745-6215
- Pmid:
-
31852488
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:1080060
- UUID:
-
uuid:a12c445d-b5d2-457a-b799-8e44a1ef2bc6
- Local pid:
- pubs:1080060
- Source identifiers:
-
1080060
- Deposit date:
- 2020-01-07
Terms of use
- Copyright holder:
- Raymond et al
- Copyright date:
- 2019
- Notes:
- © The Author(s). 2019. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License
- Licence:
- CC Attribution (CC BY)
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