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Typhoidal Salmonella human challenge studies: ethical and practical challenges and considerations for low-resource settings

Abstract:

Typhoidal Salmonella is a major global problem affecting more than 12 million people annually. Controlled human infection models (CHIMs) in high-resource settings have had an important role in accelerating the development of conjugate vaccines against Salmonella Typhi.
The typhoidal Salmonella model has an established safety profile in over 2000 volunteers in high-income settings, and trial protocols, with modification, could be readily transferred to new study sites. To date, a typh... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1186/s13063-019-3844-z

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
ORCID:
0000-0003-2309-1171
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
More from this funder
Name:
Wellcome Trust
Grant:
106698/Z/14/A milestone
106698/B/14/Z milestone
110305/Z/15/Z
096527/Z/11/Z
Publisher:
BioMed Central
Journal:
Trials More from this journal
Volume:
20
Issue:
Supplement 2
Pages:
Artice: 704
Publication date:
2019-12-19
DOI:
EISSN:
1745-6215
Pmid:
31852488
Language:
English
Keywords:
Pubs id:
pubs:1080060
UUID:
uuid:a12c445d-b5d2-457a-b799-8e44a1ef2bc6
Local pid:
pubs:1080060
Source identifiers:
1080060
Deposit date:
2020-01-07

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