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Differential expression of alternatively spliced transcripts of HLA-G in human preimplantation embryos and inner cell masses.

Abstract:

It has been reported that preimplantation human embryos secrete HLA-G, and the levels may be predictive of their ability to implant. However, it is not known which of the membrane-bound (HLA-G 1-4) and soluble (HLA-G 5-6) alternatively spliced forms are present, nor the developmental stage at which they appear. Therefore, we have investigated HLA-G mRNA isoform expression on single embryos at the two-, four-, six-, and eight-cell, morula, and blastocyst stages. The percentage of embryos expre...

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Publication status:
Published

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Authors


Barlow, DH More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Obstetrics and Gynaecology
Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
175
Issue:
12
Pages:
8379-8385
Publication date:
2005-12-05
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:a1240fdd-9273-42c0-aa61-ead6a8d4548f
Source identifiers:
248205
Local pid:
pubs:248205

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