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Major histocompatibility complex genomics and human disease.

Abstract:

Over several decades, various forms of genomic analysis of the human major histocompatibility complex (MHC) have been extremely successful in picking up many disease associations. This is to be expected, as the MHC region is one of the most gene-dense and polymorphic stretches of human DNA. It also encodes proteins critical to immunity, including several controlling antigen processing and presentation. Single-nucleotide polymorphism genotyping and human leukocyte antigen (HLA) imputation now ...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
Journal:
Annual review of genomics and human genetics More from this journal
Volume:
14
Issue:
1
Pages:
301-323
Publication date:
2013-01-01
DOI:
EISSN:
1545-293X
ISSN:
1527-8204
Language:
English
Keywords:
Pubs id:
pubs:432559
UUID:
uuid:a1234668-73d1-482e-8ff3-61329dc8eb4e
Local pid:
pubs:432559
Source identifiers:
432559
Deposit date:
2013-11-17

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