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Interdomain conformational changes provide allosteric regulation en route to chorismate

Abstract:

Multifunctional proteins play a variety of roles in metabolism. Here we examine the catalytic function of the combined 3-deoxy-D-arabino heptulosonate 7-phosphate synthase (DAH7PS) and chorismate mutase (CM) from Geobacillus sp. DAH7PS operates at the start of the biosynthetic pathway for aromatic metabolites, whereas CM operates in a dedicated branch of the pathway for the biosynthesis of amino acids tyrosine and phenylalanine. In line with sequence predictions the two catalytic functions ar...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1074/jbc.M116.741637

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Department:
Oxford, MPLS, Chemistry, Physical & Theoretical Chem
Othman, MH More by this author
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Publisher:
American Society for Biochemistry and Molecular Biology Publisher's website
Journal:
The Journal of Biological Chemistry Journal website
Volume:
291
Issue:
42
Pages:
21836 –21847
Publication date:
2016-08-08
Acceptance date:
2016-07-30
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
Pubs id:
pubs:638797
URN:
uri:a1198dcd-7df3-43e3-abba-f295b458910c
UUID:
uuid:a1198dcd-7df3-43e3-abba-f295b458910c
Local pid:
pubs:638797

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