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Inherent DNA‐binding specificities of the HIF‐1α and HIF‐2α transcription factors in chromatin

Abstract:

Hypoxia‐inducible factor (HIF) is the major transcriptional regulator of cellular responses to hypoxia. The two principal HIF‐α isoforms, HIF‐1α and HIF‐2α, are progressively stabilized in response to hypoxia and form heterodimers with HIF‐1β to activate a broad range of transcriptional responses. Here, we report on the pan‐genomic distribution of isoform‐specific HIF binding in response to hypoxia of varying severity and duration, and in response to genetic ablation of each HIF‐α isoform. Ou...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.15252/embr.201846401

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Sub department:
Target Discovery Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Sub department:
Target Discovery Institute
Role:
Author
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More from this funder
Funding agency for:
Mole, D
Grant:
NIHR-RP-2016-06-004
More from this funder
Funding agency for:
Mole, D
Grant:
NIHR-RP-2016-06-004
Publisher:
EMBO Press Publisher's website
Journal:
EMBO Reports Journal website
Volume:
20
Issue:
1
Article number:
e46401
Publication date:
2018-11-14
Acceptance date:
2018-10-17
DOI:
ISSN:
1469-221X
Keywords:
Pubs id:
pubs:937970
UUID:
uuid:a10ec6e3-3a5a-495f-b7d0-8da4490d62e2
Local pid:
pubs:937970
Deposit date:
2018-11-05

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