Journal article
Inherent DNA‐binding specificities of the HIF‐1α and HIF‐2α transcription factors in chromatin
- Abstract:
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Hypoxia‐inducible factor (HIF) is the major transcriptional regulator of cellular responses to hypoxia. The two principal HIF‐α isoforms, HIF‐1α and HIF‐2α, are progressively stabilized in response to hypoxia and form heterodimers with HIF‐1β to activate a broad range of transcriptional responses. Here, we report on the pan‐genomic distribution of isoform‐specific HIF binding in response to hypoxia of varying severity and duration, and in response to genetic ablation of each HIF‐α isoform. Ou...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 10.3MB)
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- Publisher copy:
- 10.15252/embr.201846401
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Authors
Funding
+ National Institute for Health Research
More from this funder
Funding agency for:
Mole, D
Grant:
NIHR-RP-2016-06-004
Bibliographic Details
- Publisher:
- EMBO Press Publisher's website
- Journal:
- EMBO Reports Journal website
- Volume:
- 20
- Issue:
- 1
- Article number:
- e46401
- Publication date:
- 2018-11-14
- Acceptance date:
- 2018-10-17
- DOI:
- ISSN:
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1469-221X
Item Description
- Keywords:
- Pubs id:
-
pubs:937970
- UUID:
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uuid:a10ec6e3-3a5a-495f-b7d0-8da4490d62e2
- Local pid:
- pubs:937970
- Deposit date:
- 2018-11-05
Terms of use
- Copyright holder:
- Smythies et al
- Copyright date:
- 2018
- Notes:
- Copyright © 2018 The Authors. This is an open access article under the terms of the Creative Commons Attribution 4.0 License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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