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An aqueous H+ permeation pathway in the voltage-gated proton channel Hv1.

Abstract:

Hv1 voltage-gated proton channels mediate rapid and selective transmembrane H(+) flux and are gated by both voltage and pH gradients. Selective H(+) transfer in membrane proteins is commonly achieved by Grotthuss proton 'hopping' in chains of ionizable amino acid side chains and intraprotein water molecules. To identify whether ionizable residues are required for proton permeation in Hv1, we neutralized candidate residues and measured expressed voltage-gated H(+) currents. Unexpectedly, charg...

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Publication status:
Published

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Publisher copy:
10.1038/nsmb.1826

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
Journal:
Nature structural and molecular biology More from this journal
Volume:
17
Issue:
7
Pages:
869-875
Publication date:
2010-07-01
DOI:
EISSN:
1545-9985
ISSN:
1545-9993
Language:
English
Keywords:
Pubs id:
pubs:100606
UUID:
uuid:a10d3358-0a05-4753-9fec-75b1876ec6e0
Local pid:
pubs:100606
Source identifiers:
100606
Deposit date:
2012-12-19

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