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Pharmacokinetics and clinical effects of phenytoin and fosphenytoin in children with severe malaria and status epilepticus.

Abstract:

AIMS: Status epilepticus is common in children with severe falciparum malaria and is associated with poor outcome. Phenytoin is often used to control status epilepticus, but its water-soluble prodrug, fosphenytoin, may be more useful as it is easier to administer. We studied the pharmacokinetics and clinical effects of phenytoin and fosphenytoin sodium in children with severe falciparum malaria and status epilepticus. METHODS: Children received intravenous (i.v.) phenytoin as a 18 mg kg-1 lo...

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Publication status:
Published

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Journal:
British journal of clinical pharmacology
Volume:
56
Issue:
1
Pages:
112-119
Publication date:
2003-07-05
DOI:
EISSN:
1365-2125
ISSN:
0306-5251
URN:
uuid:a0f8666f-9722-485b-bbd2-6f240f4c22cd
Source identifiers:
185611
Local pid:
pubs:185611

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