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Rapid, automated imaging of mouse articular cartilage by microCT for early detection of osteoarthritis and finite element modelling of joint mechanics.

Abstract:

OBJECTIVE: Mouse articular cartilage (AC) is mostly assessed by histopathology and its mechanics is poorly characterised. In this study: (1) we developed non-destructive imaging for quantitative assessment of AC morphology and (2) evaluated the mechanical implications of AC structural changes. METHODS: Knee joints obtained from naïve mice and from mice with osteoarthritis (OA) induced by destabilization of medial meniscus (DMM) for 4 and 12 weeks, were imaged by phosphotungstic acid (PTA) con...

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Publication status:
Published

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Publisher copy:
10.1016/j.joca.2014.07.014

Authors


Das Neves Borges, P More by this author
Vincent, TL More by this author
Marenzana, M More by this author
Publisher:
W.B. Saunders Ltd
Journal:
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society
Volume:
22
Issue:
10
Pages:
1419-1428
Publication date:
2014-10-05
DOI:
EISSN:
1522-9653
ISSN:
1063-4584
URN:
uuid:a0f81fd1-ffe1-4440-8c4d-9c6e594f525e
Source identifiers:
486192
Local pid:
pubs:486192

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