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Characterisation of placental and platelet exosome-bound cardiotrophin-1 in cardiomyocyte and endothelial cell function

Abstract:

Maternal cardiovascular adaptions during pregnancy have been well described and include characteristic changes in cardiac morphology and function. The mechanisms behind these changes remain largely unknown but are tied to the developing feto-placental unit. Extracellular vesicles are membrane-encapsulated particles carrying cargo originating from their parental cells and are critical mediators of intercellular communication. Syncytiotrophoblast extracellular vesicles (STB-EV), comprising o...

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Department:
NEW COLLEGE
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Department:
University of Oxford
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Supervisor
Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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