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Matrix metalloproteinase 9 promoter activity is induced coincident with invasion during tumor progression.

Abstract:

Matrix metalloproteinase 9 (MMP-9, also known as gelatinase B or 92-kd Type IV collagenase) is overexpressed in many human and murine cancers. We induced carcinomas in mice carrying a transgene that links the MMP-9 promoter to the reporter ss-galactosidase so that activation of the MMP-9 promoter would be indicated by ss-galactosidase. Mammary carcinomas were induced by mating the MMP-9 promoter reporter transgenic mice with mice carrying a transgene for murine mammary tumor virus promoter li...

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Publication status:
Published

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Journal:
American journal of pathology
Volume:
157
Issue:
6
Pages:
1777-1783
Publication date:
2000-12-01
DOI:
EISSN:
1525-2191
ISSN:
0002-9440
Source identifiers:
130968

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