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Pumping Ca2+ up H+ gradients: a Ca2(+)-H+ exchanger without a membrane.

Abstract:

Cellular processes are exquisitely sensitive to H+ and Ca2+ ions because of powerful ionic interactions with proteins. By regulating the spatial and temporal distribution of intracellular [Ca2+] and [H+], cells such as cardiac myocytes can exercise control over their biological function. A well-established paradigm in cellular physiology is that ion concentrations are regulated by specialized, membrane-embedded transporter proteins. Many of these couple the movement of two or more ionic speci...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics, BHF Centre of Research Excellence
Role:
Author
Journal:
The Journal of physiology
Volume:
592
Issue:
Pt 15
Pages:
3179-3188
Publication date:
2014-08-05
DOI:
EISSN:
1469-7793
ISSN:
0022-3751
URN:
uuid:a0eb0401-38a9-4942-9681-ab9e54e8f327
Source identifiers:
449048
Local pid:
pubs:449048
Language:
English

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