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Journal article

Normal radial migration and lamination are maintained in dyslexia-susceptibility candidate gene homolog Kiaa0319 knockout mice.

Abstract:

Developmental dyslexia is a common disorder with a strong genetic component, but the underlying molecular mechanisms are still unknown. Several candidate dyslexia susceptibility genes, including KIAA0319, DYX1C1 and DCDC2, have been identified in humans. RNA interference experiments targeting these genes in rat embryos have shown impairments in neuronal migration, suggesting that defects in radial cortical migration could be involved in the disease mechanism of dyslexia. Here we present the f...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1007/s00429-016-1282-1

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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Clinical Laboratory Sciences
Role:
Author
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Name:
Wellcome Trust
Grant:
090532/Z/09/Z
092071/Z/10/Z
092071/Z/10/Z
Funding agency for:
Velayos-Baeza, A
Monaco, A
More from this funder
Name:
Medical Research Council
Grant:
MR/K004387/1
Doctoral Training Award
Funding agency for:
Guidi, L
Publisher:
Springer
Journal:
Brain Structure & Function More from this journal
Publication date:
2016-08-01
Acceptance date:
2016-07-26
DOI:
ISSN:
1863-2661 and 1863-2653
Pmid:
27510895
Language:
English
Keywords:
Pubs id:
pubs:638527
UUID:
uuid:a0d7451c-555c-487f-a748-3c33af76a7a5
Local pid:
pubs:638527
Source identifiers:
638527
Deposit date:
2016-10-04

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