Automated single-trial measurement of amplitude and latency of laser-evoked potentials (LEPs) using multiple linear regression.

Journal article

OBJECTIVE: Laser stimulation of Adelta-fibre nociceptors in the skin evokes nociceptive-specific brain responses (laser-evoked potentials, LEPs). The largest vertex complex (N2-P2) is widely used to assess nociceptive pathways in physiological and clinical studies. The aim of this study was to develop an automated method to measure amplitudes and latencies of the N2 and P2 peaks on a single-trial basis. METHODS: LEPs were recorded after Nd:YAP laser stimulation of the left hand dorsum in 7 no...

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Authors: Mayhew, S; Iannetti, G; Woolrich, M; Wise, R

• Publication status: Published
• Journal: Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
• Volume: 117
• Issue: 6
• Pages: 1331-1344
• Publication date: 2006-06-01
• DOI: 10.1016/j.clinph.2006.02.017
• EISSN: 1872-8952
• ISSN: 1388-2457
• Language: English
• Keywords: Adult; Nociceptors; Pain Threshold; Linear Models; Lasers; Models, Neurological; Evoked Potentials, Somatosensory; Electroencephalography; Reaction Time; Humans; Reproducibility of Results; Female; Male; Algorithms