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Opposing effects of antibiotics and germ-free status on neuropeptide systems involved in social behaviour and pain regulation

Abstract:

Background:
Recent research has revealed that the community of microorganisms inhabiting the gut affects brain development, function and behaviour. In particular, disruption of the gut microbiome during critical developmental windows can have lasting effects on host physiology. Both antibiotic exposure and germ-free conditions impact the central nervous system and can alter multiple aspects of behaviour. Social impairments are typically displayed by antibiotic-treate...

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Publication status:
Published
Peer review status:
Peer reviewed

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Files:
Publisher copy:
10.1186/s12868-020-00583-3

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Experimental Psychology
Role:
Author
ORCID:
0000-0002-1159-2131
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Psychiatry
Role:
Author
Publisher:
BioMed Central Publisher's website
Journal:
BMC Neuroscience Journal website
Volume:
21
Article number:
32
Publication date:
2020-07-22
Acceptance date:
2020-07-07
DOI:
EISSN:
1471-2202
Language:
English
Keywords:
Pubs id:
1121254
Local pid:
pubs:1121254
Deposit date:
2020-07-27

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