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Cytogenetic analysis of human blastocysts with the use of FISH, CGH and aCGH: scientific data and technical evaluation.

Abstract:

BACKGROUND: Recent studies have suggested that biopsy of several trophectoderm (TE) cells from blastocysts followed by comparative genomic hybridization (CGH) analysis might represent an optimal strategy for aneuploidy detection, but few data on accuracy are available. The main question concerns the rate of mosaicism at the blastocyst stage, and to what extent this might cause misdiagnoses. We assessed blastocyst aneuploidy and mosaicism rates and evaluated the accuracy and efficiency of CGH...

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Publication status:
Published

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Publisher copy:
10.1093/humrep/deq344

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Journal:
Human reproduction (Oxford, England)
Volume:
26
Issue:
2
Pages:
480-490
Publication date:
2011-02-01
DOI:
EISSN:
1460-2350
ISSN:
0268-1161
Source identifiers:
248267
Language:
English
Keywords:
Pubs id:
pubs:248267
UUID:
uuid:a0c94d1e-4fae-4fa5-9628-3e6f123e5d28
Local pid:
pubs:248267
Deposit date:
2012-12-19

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