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Transcriptional signature of human pro-inflammatory TH17 cells identifies reduced IL10 gene expression in multiple sclerosis.

Abstract:

We have previously reported the molecular signature of murine pathogenic TH17 cells that induce experimental autoimmune encephalomyelitis (EAE) in animals. Here we show that human peripheral blood IFN-γ+IL-17+ (TH1/17) and IFN-γ-IL-17+ (TH17) CD4+ T cells display distinct transcriptional profiles in high-throughput transcription analyses. Compared to TH17 cells, TH1/17 cells have gene signatures with marked similarity to mouse pathogenic TH17 cells. Assessing 15 representative signature genes...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1038/s41467-017-01571-8

Authors


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ORCID:
0000-0001-5910-4910
Croonenborghs, T More by this author
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National Multiple Sclerosis Society More from this funder
Swiss National Science Foundation More from this funder
Helmut Horten Foundation More from this funder
Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Communications Journal website
Volume:
8
Issue:
1
Pages:
1600
Publication date:
2017-11-05
Acceptance date:
2017-09-29
DOI:
EISSN:
2041-1723
ISSN:
2041-1723
Pubs id:
pubs:805830
URN:
uri:a0c5a378-6033-468c-803b-407820c79a7a
UUID:
uuid:a0c5a378-6033-468c-803b-407820c79a7a
Local pid:
pubs:805830
Language:
English
Keywords:

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